Overcoming trastuzumab resistance with nordihydroguaiaretic acid?
نویسندگان
چکیده
منابع مشابه
Overcoming Trastuzumab Resistance in Breast Cancer
A targeted therapy using the antibodies Trastuzumab (Genentech, CA) developed to block HER2 signaling has been successfully used to treat patients with metastatic breast cancers that overexpress HER2. However, resistance to trastuzumab therapy is a major obstacle in the clinical management of HER2+ breast cancer. Studies have suggested an interesting association between the mechanism of resista...
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INTRODUCTION Cancer remains the leading cause of death worldwide. Numerous therapeutic strategies that include smart biological treatments toward specific cellular pathways are being developed. Yet, inherent and acquired multidrug resistance (MDR) to chemotherapeutic drugs remains the major obstacle in effective cancer treatments. AREAS COVERED Herein, we focused on an implementation of nanos...
متن کاملPreclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
PURPOSE We have previously shown that PTEN loss confers trastuzumab resistance in ErbB2-overexpressing breast cancer using cell culture, xenograft models, and patient samples. This is a critical clinical problem because trastuzumab is used in a variety of therapeutic regimens, and at the current time, there are no established clinical strategies to overcome trastuzumab resistance. Here, we did ...
متن کاملNordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer.
The majority of patients with HER2-overexpressing metastatic breast cancer who initially respond to the HER2-targeted antibody trastuzumab show disease progression within 1 year. The identification of novel agents that effectively inhibit survival of cancer cells that have progressed on trastuzumab is critical for improving outcome for this patient population. In the current study, we show that...
متن کاملOvercoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.
Trastuzumab shows remarkable efficacy in treatment of ErbB2-positive breast cancers when used alone or in combination with other chemotherapeutics. However, acquired resistance develops in most treated patients, necessitating alternate treatment strategies. Increased aerobic glycolysis is a hallmark of cancer and inhibition of glycolysis may offer a promising strategy to preferentially kill can...
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ژورنال
عنوان ژورنال: Breast Cancer Research and Treatment
سال: 2005
ISSN: 0167-6806,1573-7217
DOI: 10.1007/s10549-005-9081-z